How do we assist local, state, and federal health communicators in tailoring message executions to enhance target audience compliance? In response to this question and the need for a standardized tool for long-lead time message development, the Centers for Disease Control and Prevention (CDC) Division of Cancer Prevention and Control (DCPC) and the Oak Ridge Institute for Science and Education (ORISE) created a Message Development Tool. During the Panel discussion, panelists will introduce a prototype of the Message Development Tool including its purpose and objectives, innovative design process, evidence-based model, and key features. The first panelist, Dr. Galen Cole, will provide the background and purpose of the Message Development Tool and describe the results of the Expert Panel Meeting that assisted in the tool's design. The second presenter, Dr. Punam Keller, will describe her extensive meta-analysis of the main and interaction effects of message tactics and individual characteristics on intentions to comply with health recommendations. From her research, Dr. Keller produced an empirical model on which the Message Development Tool is based. The final panelist, Ms. Eileen Haag, will demonstrate the key features and functionality of the Message Development Tool.