Advances in technology allow people to meaningfully new ways of communicating and methods of disseminating information to the public. The Centers for Disease Control and Prevention has created 3 exciting health communication projects that engage the public using novel health communication methods. These projects seek to educate the public about the adopting behaviors necessary to optimize the public’s health in the areas of emergency preparedness for natural and public health disasters, nutrition, Human Immunodeficiency Virus (HIV) and other Sexually Transmitted Infections (STI). The purpose of this panel session is to highlight the successful development and/or execution of CDC’s Zombie Apocalypse, Chromosome and the HIV/STI Focused Motion Comic (MoCom) projects.