Results: At 7 days after the initiation of the reporting system, reporting rate of earthquake zone through the MIS have reached the level of the same period in 2007. The surveillance of weekly morbidity reporting in the earthquake zone after the initiation of mobile phone based information system for infectious disease reporting showed the same trend with the last 3 years. Conclusions: Emergency response MIS for Infectious Disease Reporting was an effective solution for the urgent reporting and management of communicable disease surveillance information. The system assured the consistency of disease surveillance data and facilitated sensitive, accurate and timely disease surveillance. It is an important resource to supplement the normal national web-based direct reporting system of communicable diseases. The system picked up at least as many disease cases as were picked up manually in the past 3 years. This paper will present an open discussion of recommendations for further use of mobile-based emergency response systems.