The findings and conclusions in these presentations have not been formally disseminated by the Centers for Disease Control and Prevention and should not be construed to represent any agency determination or policy.

Wednesday, March 12, 2008 - 10:15 AM
C5a

Implications of the variant strain of Chlamydia trachomatis (CT) circulating in Sweden

Charlotte A. Gaydos, Division of Infectious Diseases, Medicine, Johns Hopkins University, 1159 Ross Bldg, 720 Rutland Ave, Baltimore, MD, USA

A CT variant (mutant) has been characterized by a 377 base pair deletion in the cryptic plasmid of 7501 bp in serovar E. Some NAATs target the plasmid: Roche Cobas Amplicor PCR/TaqMan 48, Abbott m-2000, and Becton Dickinson-ProbeTec. Other tests target other genes/targets and are not affected for detection: GenProbe Aptima targets the 16S rRNA gene, Artus-RealArt CT-PCR targets the omp-1 gene. Because of primer annealing location on the plasmid, both the Roche Cobas-Amplicor PCR/TaqMan 48 and the Abbott m-2000 will not identify the variant CT. Redesigning the primers to anneal to another plasmid-location would restore detection of the variant.

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