Detection of syphilis and HSV in MSM

Both syphilis and herpes simplex virus (HSV) infections have been associated with HIV transmission and acquisition. Men who have sex with men (MSM) should have screening serologic tests for syphilis performed at least yearly and more frequently if they engage in high risk behaviors. Some experts recommend serologic testing for HSV for those who request testing and, in particular, for HIV-infected individuals. Serologic tests for both infections, however, are not perfect. Discussion will center upon currently available serologic tests for syphilis and HSV, test interpretation pitfalls, interpretation of test results for the patient, and the importance of testing for MSM.