P13 Disparities in Symptomatic Chlamydia Infection at Diagnosis Among Women in Minnesota

Tuesday, March 9, 2010
Pre-Function Lobby & Grand Ballroom D2/E (M4) (Omni Hotel)
Ruby Nguyen, PhD1, Summer Martins, MPH2, Glenise Johnson, MPH3, Luisa Pessoa-Brandão, MS2 and Rahel Ghebre, MD4, 1Division of Epidemiology & Community Health, University of Minnesota, Minneapolis, MN, 2STD and HIV Section, Minnesota Department of Health, St. Paul, MN, 3Infectious Disease Epidemiology, Prevention & Control Division, STD & HIV Section, Minnesota Department of Health, St. Paul, MN, 4Division of Obstetrics and Gynecology, University of Minnesota, Minneapolis, MN

Background: Adequate screening of high-risk women may lower rates and complications of Chlamydia (Ct) infection among communities with high morbidity.

Objectives: To evaluate gaps in Ct screening coverage, we sought to identify factors associated with being symptomatic at diagnosis among women in Minnesota.

Methods: Using the Minnesota Department of Health STD Surveillance System, 2004 – 2008, we identified females who were laboratory-confirmed Ct cases.  Characteristics that could be associated with symptomatic status were taken from the confidential case report.

Results: Over our study period 46,760 Ct cases were reported among females, 7,667 (16.4%) of whom were pregnant.  Rates of symptomatic infection at diagnosis were lower among pregnant women versus non-pregnant (23.5% vs. 37.9%, p<0.001, respectively), however, race modified this association.  Among pregnant women, 18.3% of White and 33.5% of Black women were symptomatic, while 32.9% of White and 47.8% of Black non-pregnant counterparts were symptomatic.  Age, calendar year, metropolitan location, and type of clinic were also significant univariate factors of symptomatic status.  Using a multivariate logistic regression for non-pregnant women, metropolitan women were 20% more likely than non-metropolitan women to be symptomatic at diagnosis for Ct (95% CI: 1.13 – 1.26), whereas Black, Native American, and Multi-Race women were significantly more likely than White women to be symptomatic (adj. ORs = 1.40, 1.25, 1.46, respectively).  When examining pregnant women, these factors were more likely associated with symptomatic status at diagnosis; metropolitan (adj. OR = 1.98), Black (1.68), Native American (1.52), and Multi-Race (1.51).

Conclusions: Drastic disparities exist when examining factors associated with symptomatic cases of Ct.  Testing during pregnancy may reduce the overall rate of symptomatic infection, but the disparities are even greater.

Implications for Programs, Policy, and/or Research:  Targeted screening programs could be implemented among communities with significantly higher rates of symptomatic infections.

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