P179 Seroprevalence of Herpes Simplex Virus Type 2 National Health and Nutrition Examination Surveys (NHANES), United States, 20052008

Tuesday, March 9, 2010
Pre-Function Lobby & Grand Ballroom D2/E (M4) (Omni Hotel)
La'Shan Taylor, DrPH, MPH, MS1, Maya Sternberg, PhD2, Sami L. Gottlieb, MD, MSPH1, Fujie Xu, MD, PhD1, Stuart Berman, MD, ScM3 and Lauri Markowitz, MD4, 1Division of STD Prevention, CDC, Atlanta, GA, 2Centers for Disease Control and Prevention, Atlanta, GA, 3Division of STD Prevention, Epidemiology and Surevillance Branch, Centers for Disease Control and Prevention, Atlanta, GA, 4Division of STD Prevention, Centers for Disease Control and Prevention, Atlanta, GA
Seroprevalence of Herpes Simplex Virus Type 2 National Health and Nutrition Examination Surveys (NHANES), United States, 20052008

Background: Herpes simplex virus type 2 (HSV-2), the main cause of genital herpes, causes lifelong infection and increases the risk of HIV acquisition by at least 2-fold. HSV-2 seroprevalence has been assessed in National Health and Nutrition Examination Surveys (NHANES) since 1976, with seroprevalence decreasing during the past decades (1988-1994 = 21%; 1999-2004= 17%).

Objectives: We sought to determine the U.S. HSV-2 seroprevalence estimates from NHANES 2005-2008.

Methods: We analyzed data from NHANES 20052008 to establish the seroprevalence of HSV-2 among persons aged 1449. Data were weighted to provide national estimates. Logistic regression was used to identify factors associated with HSV-2 seroprevalence. HSV-2 seroprevalence from NHANES 20052008 was compared with estimates from NHANES 1999-2004.

Results: In NHANES 20052008, the overall HSV-2 seroprevalence was 16.2% (95% confidence interval 14.6%17.9%). Seroprevalence increased with age, from 1.4% among those aged 1419 to 26.1% among those aged 4049, and was higher among women (20.9%) than among men (11.5%, p<0.001). Seroprevalence was higher among non-Hispanic blacks (39.2%) than among non-Hispanic whites (12.3%, p<0.001). HSV-2 seroprevalence did not change between 1999-2004 and 2005-2008 (p=.34)

Conclusions: In the United States, approximately 1 in 6 persons aged 1449 years has HSV-2 infection; women and African Americans were found to be disproportionately affected.

Implications for Programs, Policy, and/or Research: HSV-2 infection has particular public health importance because it increases the risk of HIV acquisition, and groups with the highest HSV-2 seroprevalence (e.g., non-Hispanic blacks) are at higher risk of acquiring HIV. Primary prevention of HSV-2 infection may be the only method to reduce the excess HIV risk associated with HSV infection in these groups.

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