Abstract: Rectal HPV Infection in Men: Associations with Demographics, Drug Use and HIV Infection (2010 National STD Prevention Conference)

Wednesday, March 10, 2010: 11:45 AM

Grand Ballroom C (M4) (Omni Hotel)

Ryan Murphy, MPH¹, Pamina Gorbach, DrPH², Robert Weiss, PhD³, Ross Cranston, MD, FRCP⁴, Christopher Hucks-Ortiz, MPH⁵, Maria Da Costa⁶ and Steven Shoptaw, PhD⁵, 1Department of Epidemiology, University of California Los Angeles, Los Angeles, CA, 2Department of Epidemiology, UCLA, Los Angeles, CA, 3Department of Biostatistics, UCLA School of Public Health, Los Angeles, CA, 4Division of Infectious Disease, University of Pittsburgh Medical Center, Pittsburgh, PA, 5Department of Family Medicine, David Geffen School of Medicine at UCLA, Los Angeles, CA, 6Department of Medicine, Division of Infectious Diseases, University of California San Francisco, San Francisco, CA

Audio File Recorded presentation

Background: There is little known about behavioral risk factors for rectal HPV infection among men.

Objectives: Identify relationships between demographics, substance use and rectal HPV infection.

Methods: From 2005-2007, 622 men from a respondent driven sample in Los Angeles part of NIDA's Sexual Acquisition and Transmission of HIV Cooperative Agreement Program completed Audio Computer Assisted Self Interviews, were tested for recent methamphetamine use via urine, HIV by rapid oral test with confirmatory blood test, and for rectal HPV. Associations with HPV, HRHPV and Multiple-HRHPV and demographics, substance use, sexual behaviors and HIV status were tested with logistic regression. Generalized linear random intercepts models were fit to predict unprotected receptive anal intercourse (URAI) with up to three of their last partners.

Results: Participants were middle aged, minority, and lower income. HPV, HRHPV and multi-HRHPV prevalence was 65.9%, 36.8%, 13.7% respectively. Methamphetamine use was associated with HPV (OR 4.1 95% CI 1.6-10.6) and HRHPV (OR 3.4 95% CI 1.8-6.5). In multivariate models predicting any HPV age>50 versus age<30 (AOR: 3.0, 95%CI 1.2-7.5), MSMW versus MSM (AOR 0.39, 95% CI 0.22-0.70), HIV+ (AOR 7.1, 95% CI 3.8-13.4) and having URAI (AOR 1.6, 95% CI 1.1-2.5) were significant. For HRHPV being HIV+ (AOR 5.8, 95% CI 3.6-9.4) and MSMW versus MSM (AOR 0.56, 95% CI 0.32-0.97) were significant. For multi-HRHPV, being HIV positive (AOR12.2, 95% CI 5.5-27.1) and African American (AOR 0.39, 95% CI 0.19-0.80) were significant.

Conclusions: Findings highlight the high prevalence among HIV positive men. Demographic, drug and sexual behavior variables association with HPV indicate a potential role in HRHPV transmission.

Implications for Programs, Policy, and/or Research: Strong associations between HRHPV and HIV reiterates that testing is essential for positive men; more research is needed with HIV negative men to determine associations with demographics, drug use and sexual behaviors and HRHPV infection.

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