New technologies and interventions are added to the HIV/STI prevention tool box on a regular basis. Familiarity and understanding about when and for whom they are most beneficial has an impact on their uptake and subsequent their effectiveness in preventing HIV and other STIs. This session will explore three areas of recent interest in STI/HIV prevention and how they interface with reactions to them. The first two presentations explore prevention strategies for people at high risk for acquiring new HIV infections. The first talk focuses on the practice among many MSM of serosorting on HIV status, an effort to both limit unprotected sex to partners of the same HIV status and reduce risk of acquiring or transmitting HIV. The second focuses on Pre-Exposure Prophylaxis or “PrEP;” the use of antiretroviral therapies prior to HIV exposure in order to reduce new HIV infections. This review of PrEP will include discussion about its potential impact on prevention behaviors related to HIV and STIs. Because both of these strategies may impact other STIs differently than HIV, it is important that health providers fully understand the concepts and prevention implications in order to coordinate effective health messages. The last talk will discuss the most recent recommendations for the HPV vaccines from the Advisory Committee on Immunization Practice, new data from HPV vaccine trials, the status of the HPV vaccine program in the United States, and future public health directions for use of this exciting new STI prevention tool.