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P171 Incident Sexually Transmitted Infections in Adolescent Males Participating in the Young Men's Project

Tuesday, March 13, 2012
Hyatt Exhibit Hall
James Williams, BS1, Barbara Van Der Pol, PhD, MPH2, Deming Mi, MS3, Laura Hires, BS1, Cheryl Denski, BG3 and J. Dennis Fortenberry, MD, MS4, 1Department of Medicine, Indiana University School of Medicine, Indianapolis, IN, 2Indiana University School of HPER, Bloomington, IN, 3Department of Biostatistics, Indiana University School of Medicine, Indianapolis, IN, 4Department of Pediatrics, Indiana University School of Medicine, Indianapolis, IN

  

Background:  The goal of the Young Men’s project is to characterize the urethral microbiome in a cohort of multi-ethnic adolescent males as they progress through puberty. In order to increase our understanding of the urethral micro-environment in this population, behavioral and symptomologic data, along with longitudinal urine samples were collected from each participant.

Objectives:  To determine incident STI and the association between white blood cell (WBC) count and STI status in a newly established cohort of adolescent males.

Methods:  Adolescent males, ages 14-17, were enrolled from an urban setting using community based recruitment. Urine samples were collected monthly from each participant and tested for C. trachomatis (CT), N. gonorrhoeae (NG), and T. vaginalis (TV) by NAAT; urinalysis was performed on each sample to assess WBC count. The rate of incident infection was expressed as the number of new infections for CT, NG, or TV identified per 100 person months of follow-up. A generalized linear mixed model with zero-inflated Poisson distribution was used to assess the association between WBC count and STI status.

Results:  54 participants contributed a total of 728 months of follow-up. Incident infection was determined to be 1.2, 0.1, and 0.4 per 100 person months of follow-up for CT, NG, and TV, respectively. A positive result for an STI was associated with a higher urine WBC count (p < 0.001).

Conclusions:  STI infection was low in this cohort of adolescent males; however, there was a strong association between urine WBC count and STI status.

Implications for Programs, Policy, and Research:  Adolescent males showed a willingness to participate and provide urine samples for testing. This study may lead to a better understanding of the relationship between STI, immune response, and microflora found in maturing adolescent males. Cumulative experience in this cohort may improve targeting and participation of adolescent males in community based screening programs.

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