High Rates of Incident Anogenital Human Papillomavirus Infection Among Teenage Men Who Have Sex with Men

Zou, Huachun

Tuesday, June 10, 2014

Exhibit Hall

Huachun Zou, MD, MS and PhD¹, Sepehr Tabrizi, MS PhD FFSc(RCPA) FASM², Andrew Grulich, PhD³, Suzanne Garland, PhD⁴, Jane Hocking, PhD⁵, Catriona Bradshaw, PhD⁶, Andrea Morrow, Nurse⁷, Garrett Prestage, PhD⁸, Alyssa Cornall, MS⁹, Marcus Chen, PhD¹⁰ and Christopher Fairley, PhD⁶, 1School of Population Health, The University of Melbourne, Carlton, Australia, 2The Royal Womens Hospital, Parkville, Australia, 3Kirby Institute, University of New South Wales, Sydney, Australia, 4Department of Microbiology and Infectious Diseases Laboratory Services, Royal Women's Hospital, Parkville, Australia, 5Melbourne School of Population and Global Health, University of Melbourne, Carlton, Australia, 6Melbourne Sexual Health Centre, The Alfred Hospital, Melbourne, Australia, 7Melbourne Sexual Health Centre, Alfred Health, Australia, 8Kirby Institute, University of New South Wales, 9Department of Microbiology and Infectious Diseases, Royal Women’s Hospital, 10School of Population and Global Health, University of Melbourne

Background:

Anogenital human papillomavirus (HPV) infection among men who have sex with men (MSM) is common, leading to morbidity including anal cancer. This study sought to elucidate incident anogenital HPV infection among teenage MSM.

Methods:

We estimated incident type-specific HPV infection by HPV DNA from the anal canal and penis among 200 MSM aged 16 to 20 years in Melbourne, Australia. Men were seen at baseline, then month 3, 6 and 12. HPV infection refers to DNA of a specific type of HPV tested negative at baseline and positive at two or three follow-up visits.

Results:

Median age was 19 years. At baseline, men reported a median duration of 1.9 years since first receptive anal sex and a median of 4 receptive anal sex partners. The incidence rates for infection of any, any high risk, any low risk and any 4-valent vaccine preventable HPV at the anus were 54.7 (95% confidence interval (CI): 41.7-67.2), 26.6 (95% CI: 16.5-38.6), 35.7 (95% CI: 24.5-48.5) and 30.6 (95% CI: 19.9-42.7) per 100 person years, respectively. The incidence rate for infection of anal HPV 16 was 5.8 (95% CI: 1.6-14.2) per 100 person years. The incidence rates for infection of any, any high risk, any low risk and any 4-valent vaccine preventable HPV at the penis were 7.2 (95% CI: 2.0-17.3), 7.1 (95% CI: 2.0-17.0), 3.5 (95% CI: 0.4-12.1) and 5.3 (95% CI: 1.1-14.6) per 100 person years, respectively. The proportions of men with incident anal and penile warts were 2.2% (4/186, 95% CI: 0.6-5.4) and 0.5% (1/199, 95% CI: 0.0-2.8), respectively.

Conclusions:

Incident anogenital HPV was high and occurred soon after first sexual experiences among teenage MSM. HPV vaccination needs to commence early for maximal prevention of HPV among MSM.

TP 28 High Rates of Incident Anogenital Human Papillomavirus Infection Among Teenage Men Who Have Sex with Men