WP 170 Gardnerella Vaginalis Infection in Women Infected with HIV or AIDS in Specialized Assistance Services - STD/AIDS, Amazon, Brazil

Tuesday, June 10, 2014
International Ballroom
Leila Silva, Leila C.F. Silva1, Angelica Espinosa Miranda, Angelica Miranda2, Rosieny Batalha, Rosieny S. Batalha3, Geraldo Soares, Geraldo Magela4 and SinÚsio Talhari, SinÚsio Talhari2, 1STD/Aids Manangement and Center Information Systems, Post Graduation Program in Tropical Medicine, Tropical Medicine Foundation Dr. Heitor Vieira Dourado/State University of Amazon, Brasil and Foundation for Health Surveillance, Brazil, Manaus, Brazil, 2Post Graduation Program in Tropical Medicine, Tropical Medicine Foundation Dr. Heitor Vieira Dourado/State University of Amazon, Brasil, 3STD/Aids Manangement, Tropical Medicine Foundation Dr. Heitor Vieira Dourado, Brazil, 4Bacteriology Laboratory, Tropical Medicine Foundation Dr. Heitor Vieira Dourado, Brazil

Background: The Gardnerella vaginalis infection in HIV-infected women may increase their infectiousness and susceptibility genital. We sought to determine the prevalence of infection by G. vaginalis in HIV/AIDS women and associated factors.

Methods: Sectional study (2009-2011) of women infected with HIV/AIDS in AIDS clinic, Amazonas, Brazil. A questionnaire was composing for demographic, behavioral and clinical variables. Exudate collected from the bottom of vaginal fornix for diagnosing G. vaginalis by Gram stain and cervical samples for HPV/Capture Híbrida2v2 and cytology test. Analysis included frequency distribution, median and interquartile range/IQR. Prevalence of infection was estimated by the presence of positive test (95%CI). Associations test, Chi-square. The study was approved by the Ethics in Research Committee (1962-2009/FMT-HVD).

Results: 333 (89.03%) of 374 women were included in the study. G. vaginalis was detected in 121 (36.3%) cases. Of this total, 75 (67.0%) were coinfected with HPV, 14 (12.5%) had cervical intraepithelial neoplasia grade I (CIN) and 1 (0.9%) CIN-II/III, 66 (56.4%) had viral load HIV-1 >1,000 copies/ml (p-value = 0.005). The most frequent age group 30-39 years (51/42.1%), median: 32 (IQR-38/27), 62(51.2%) had more than 9 years of education, 60 (49.6%) were married, 67 (55.4%) had income of 1 BMI, 108 (89.3%) were non-smokers, 62 (51.7%) had their first sexual intercourse with age >16 years, 82 (81.2%) used condoms with their partners and 81 (66.9%) as a contraceptive method, 20 (16.7%) were sex workers, 79 (67.0%) had anal sex practices and 4 (3.4%) homosexuals, 73 (60.6%) had vaginal discharge, 62 (51.2%) vaginal itching and 68 (56.2%) pelvic pain, 34 (28.3%) had CD4+ counts between 201-349 cells/mm3, 61 (50.8%) had AIDS.

Conclusions: Infection with G. vaginalis in HIV/AIDS women shows their susceptibility to genital infections through sexual transmission. Co-infection by HPV, and presence of CIN, reinforces the urgent need for specific prevention of STD in this population.