At least 35 pathogens are transmitted through sex. Although STD programs with limited resources reasonably focus on the most common infections (e.g., chlamydia and gonorrhea), awareness of other sexually-transmissible microbes is critical to building strong prevention, screening and treatment programs. This symposium will examine three pathogens not typically considered sexually transmitted. Neisseria meningitidis (Nm) is a Gram-negative diplococci that colonizes the nasopharynx and rarely infects the urogenital tract. However, at least two clusters of Nm-associated urethritis among largely heterosexual, HIV-negative men have appeared in the Midwestern US in 2015 and 2016. Shigella is transmitted through oral exposure to the stool of an infected person. Men who have sex with men (MSM) are more likely to acquire Shigella compared to other adults. Antibiotic resistant strains are common, and HIV-infected MSM can have severe shigellosis, including bacteremia. Hepatitis C virus (HCV) is spread primarily through contact with the blood of an infected person. MSM, particularly those reporting higherrisk sexual behaviors, appear to have increased HCV prevalence. These talks will review the evidence supporting sexual transmission of these pathogens, describe the affected populations, examine behaviors increasing risk of transmission, review screening and treatment guidelines, and provide updates on the epidemiology of recent outbreaks.