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Learning Objectives for this Presentation:
By the end of the presentation participants will be able to (1) name four factors that are associated with a higher proportion of HIV-infected persons being co-infected with hepatitis C (HCV), and (2) describe the impact of HIV-co-infection on HCV disease progression.
Background:
The aging of the cohort of HCV-infected persons in the U.S. population is expected to produce a sharp increase in the number of persons developing advanced liver disease. HIV co-infection increases this risk.
Methods:
Data were collected from the medical records of patients receiving HIV-related medical care at two medical centers in Detroit, for the Adult and Adolescent Spectrum of Disease, a CDC-sponsored, multi-site, HIV/AIDS surveillance project.
Results:
Eighteen percent (370) of the 2065 persons receiving HIV-related care during the three-year period, 2000-2002, were co-infected with HCV. Of persons who reported injection drug use as their HIV transmission risk, 46% were co-infected with HCV, in contrast to only 5% of persons with sexual HIV transmission risk factors (MSM or heterosexual). Among HIV-infected persons with white race recorded, 10% of men and 26% of women were co-infected with HCV, while among African Americans, men (20%) and women (18%) were equally affected. The distribution of co-infected persons by race and sex mirrored the distribution of injection drug users, as would be expected since 79% of co-infected persons reported injection drug use as their HIV transmission risk. HIV-infected persons over 40 years of age were more likely to be co-infected with HCV than younger persons. This observation was consistent with the age distribution of HCV infection in the general population.
Conclusions:
The race, sex, and age profiles of HIV/HCV co-infected persons reflected the strong correlation between HCV infection and a history of injection drug use. HCV co-infection will complicate the care of an increasing proportion of HIV patients over the coming decade or longer.
See more of F2 - Education and Resources for Persons Co-infected with HIV and HCV
See more of The 2005 National Viral Hepatitis Prevention Conference