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Learning Objectives for this Presentation:
Learning Objective for this presentation: By the end of this presentations participants should be able to quantify the mortality risk associated with CHB infection.
Background:
Background: The long term hepatic sequelae of chronic hepatitis B (CHB) infection have been well documented. We evaluated the mortality risk associated with CHB infection in a large prospective cohort study.
Methods:
A community based prospective cohort study was established from 7 townships in Taiwan between 1991 and 1992. Mortality causes were identified through computerized data linkage to the Taiwanese National Cancer Registry, National Death Certificate Registry and National Health Insurance profiles through December 31st 2002. Incidence rates were calculated and multivariable adjusted relative risk (RRadj) derived from Cox proportional hazard models.
Results:
Of 23,820 subjects, 1,545 (6.4%) died. Malignant neoplasms (37%), circulatory system diseases (20%), injury and poisoning (13%), GI disorders (8%), and diabetes mellitus (6%), were the five leading causes of death. Of the enrolled subjects, 4,155 (17.4%) were HBsAg-positive; the RRadj (95% CI) for all cause mortality for the HBsAg-positive group was 1.7 (1.5-1.9) compared with the HBsAg-negative group. The RRadj (95% CI) was 10.8 (7.7-15.2) and 5.4 (3.4-8.6) for liver cancer and chronic liver disease deaths, respectively. The RRadj (95% CI) for all other causes of mortality was 1.1 (0.9-1.3).
Conclusions:
CHB infected subjects had a significant risk of excess mortality compared to non-infected subjects. Increases in liver related mortality account for the mortality differences. Early intervention with appropriate anti-viral therapies may decrease liver related complications and prolong survival in these individuals.
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See more of The 2005 National Viral Hepatitis Prevention Conference