Today parents have questions about immunization and vaccine safety and these concerns may be serious enough for some parents to choose to not fully vaccinate their children against serious and sometimes deadly vaccine-preventable diseases. CDC’s National Center for Immunization and Respiratory Diseases (NCIRD) has undertaken a structured series of research projects to gain knowledge in the best ways to provide clear, consistent, and timely immunization information to parents to assist them in making informed decisions about vaccination. In 2009, based on information gleaned from a variety of research methods, NCIRD launched a new suite of resources, Provider Resources for Vaccine Conversations with Parents, that provides clinicians, healthcare providers, public health partners, and health educators with messages, materials, and tools they need for the most effective communication practices—in this case, effectively addressing parents’ questions and supporting parents in their vaccination decisions. This panel will provide information on CDC’s up-to-date qualitative and quantative research on parent and healthcare provider knowledge, attitudes and behaviors about vaccination and share how this research, combined with science-based communications strategies and risk communication principles, was used to inform the development of communication strategies, immunization messages, and materials. The panel will also discuss marketing and dissemination strategies and the critical role partners played in the development, dissemination, and evaluation of these new materials.