The presenters in this session describe three successful approaches to reaching youth and influencing their sexual health knowledge, attitudes, and behavior. Two campaigns for teens on pregnancy prevention and teen vaccinations developed innovative, creative, and “cool” teen-centric approaches tailored to their audiences’ needs for accurate, but fun and empowering messages. #SpeakOutHIV uses digital storytelling to empower LGBTQ youth with the knowledge and skills to speak out about HIV where they are – on social media – through personal videos. The I MATTER Teen Pregnancy Prevention Program collaborated with youth to develop a multi-media campaign, including web and social media messages, to connect them with reproductive health services.