Despite decades of research and outreach, rates of conditions resulting from risky behaviors continue to pervade public health. The panelist n this session will present completely unique program approaches to reach MSM and increase use of condoms; talk to teens about responsible sexual and reproductive health; and combat the dangers of synthetic marijuana (aka, “fake weed”) among youth. These are not simple issues, but the understanding of the audiences and the cultural influences that play a role have led to innovative ideas to motivate change.