Although sexually transmitted diseases (STD) affect people of all ages, adolescents continue to experience a disproportionate burden accounting for half of the 20 million new STDs in the US each year. With some rates of STDs increasing among this vulnerable population, innovative methods to reach youth for research, prevention and education remain critical. In the first presentation, Ms. Kachur will describe current trends in adolescent use of social media and mobile phone applications and will provide examples of ways in which technology can, and has been, incorporated into research and prevention efforts. The second presentation will focus on Detroit’s school-based STD screening program, which is the first such program to be associated with a sustained reduction in chlamydia prevalence. LCDR Dunville will describe mathematical modeling and other innovative approaches CDC is taking to explain these results within the context of other school-based screening programs. In the third presentation, Ms. Le Backes will discuss the development and evaluation of the Hulu original series, East Los High, an innovative multi-platform program that incorporates entertainment-education to reach Latino youth with information on STDs and sexual and reproductive health.