The National Cancer Institute’s Office of Communications and Education (OCE) disseminates cancer information and research to diverse audiences through multiple channels. OCE informs audiences using proven health communication research methods and techniques. These methods incorporate a user-centered approach to provide the right information to the right audiences at the right time. We will describe four user-centered approaches – Making Data Talk; P.L.A.N.E.T. Step 2; Multicultural Media Outreach; and CancerSPACE – tailored to inform and educate diverse audiences about health information. Collectively, these interventions support NCI’s mission to move research to practice. Making Data Talk describes ways to effectively communicate public health data to lay audiences, critical to raise awareness and make informed decisions on important health issues. The content is being disseminated through workshops and through development of a workbook for use by public health students and practitioners. Adapting research-tested interventions with “fit and fidelity” is a complex process. Through a web-based approach, Cancer Control P.L.A.N.E.T. Step 2 is building a virtual community of practice. Researchers and practitioners interact through a series of cyber seminars to share lessons learned. From didactic webinars to interactive social media, OCE’s multicultural media outreach program engages ethnic populations using tailored approaches to disseminate cancer information through YouTube and Twitter. CancerSPACE uses “gaming” as an educational tool, combining technology with adult learning principles. This interactive, web-based application is designed to support staff in community health centers. The simulated environment allows practitioners to integrate information by “practicing” new approaches and building confidence to overcome real world clinic challenges.