Quality-control lapses in healthcare facilities may put patients at risk of infection. When these practices or the resulting infections are identified, a patient notification is typically initiated. In recent years, most patient notifications have been associated with unsafe injection practices. In 2009, CDC initiated efforts to improve these patient notifications and develop best practices for future notifications. CDC held stakeholder meetings, conducted focus groups to test and improve patient notification letters, and consulted with patient advocates, healthcare providers, and public health leaders to ensure that future patient notifications followed best practices compiled from previous notification events. When patients receive a notification phone call or letter, they may become overwhelmed with a mix of emotions – fear, loss of trust, and lack of control. Following risk communication principles during patient notifications is critical to addressing these concerns. Past patient notification events have highlighted the need to give clinicians and patients concrete action steps that are essential for assisting individuals who are feeling a “loss of control” in the situation to be able to exercise their ability to take back control of their health and the situation. The outbreak of fungal meningitis and other infections, beginning in 2012, is one of the largest healthcare-associated outbreaks in U.S. history. CDC, working closely with state and U.S. Food and Drug Administration counterparts, was able to establish a model platform for crisis communications. Media monitoring demonstrated that the public considered CDC to be a trusted information source.