Men who have sex with men (MSM) are disproportionately impacted by HIV: in 2011, 62% of all HIV diagnoses were attributed to male-to-male sexual contact. The Prevention Communication Branch (PCB) in the Division of HIV/AIDS Prevention at CDC is developing a number of communication efforts for gay, bisexual, and other MSM to help combat HIV. The two overarching efforts are the development of an interactive HIV Risk Reduction Guide and the Act Against AIDS campaign (AAA). In 2009, CDC launched AAA, an umbrella campaign that houses distinct campaign efforts to reach the general population, individuals at high-risk for developing HIV, people living with HIV/AIDS, and healthcare providers. Since the launch of AAA, we have conducted formative research for four campaigns targeting openly gay and bisexual men. Another activity within PCB is the development of an HIV Risk Reduction Guide. Although this interactive Guide targets all adults, much of the formative research, included expert consultations and message testing, have focused on and included MSM. In total, we have interviewed or surveyed over 1200 MSM. We have hosted 7 expert consultations, bringing together individuals from academia, clinical settings, media companies, government, and community-based organizations to provide recommendations for our communication efforts. We have conducted 14 rounds of message, concept, or materials testing. We have conducted research via online surveys, in-depth interviews, dyads and triads. This panel synthesizes the wide range of research activities produces some best practices for how to reach and engage MSM with effective messages and materials.