This session highlights the experience with using Health Information Exchange (HIE) data and clinical practice data to answer questions of great importance to public health. One research institute will describe their experience between linking patient electronic health record data stored in an HIE with geospatial and community data housed in a community information system. A city health department will describe their experience with querying supported electronic health record vendors, sending alerts based on the outcome of these queries, and combining these data with other surveillance datasets in the city’s data warehouse to form an aggregate, de-identified population health record. And lastly, the National Cancer Insitiute will showcase moving research into practice using a virtual community.