Background/Purpose: Methamphetamine use is associated with risk behavior and HIV/STDs, particularly among MSM. CDC funded an initiative to relatively quickly identify risk-reduction approaches that may be effective with this population, and to assist the field in identifying promising interventions for further research. Objectives of Symposium: To present pre-post test results for four independent, non-treatment based interventions pilot tested among methamphetamine-using MSM, including: a couple-based program for black, methamphetamine-using, MSM couples in New York; a 1-session motivational interviewing program for MSM in North Carolina; a 2-week, customized texting program for MSM in Los Angeles; and a six-session, toolbox intervention for HIV+ and HIV-, injecting and non-injecting, methamphetamine-using MSM in San Diego. We assessed sexual and drug-using risk behavior at baseline and at 2-month post-intervention follow-up for each site. Implications for Programs, Policy, and/or Research: Panelists will discuss site-specific results and related implications for their intervention (see below), and future directions for their research and other programs designed to work with methamphetamine-using MSM.